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Eosinophilic esophagitis
 
Saurabh Kedia, Bhaskar Jyoti Baruah, Govind Makharia, Vineet Ahuja
Department of Gastroenterology,
All India Institute of Medical Sciences,
New Delhi, India


Corresponding Author
: Dr. Vineet Ahuja
Email: vineet.aiims@gmail.com


Abstract

Eosinophilic esophagitis (EoE) is a clinico-pathological entity characterised by symptoms of esophageal dysfunction and eosinophilia on esophageal mucosal biopsies in the absence of other causes of esophageal eosinophilia. It is a chronic inflammatory condition of esophagus often characterized by refractory reflux symptoms in children and dysphagia in adults. It occurs as a result of Th2 inflammatory response to environmental triggers (food antigens) in genetically predisposed individuals. The diagnostic criteria include symptoms of esophageal dysfunction, esophageal eosinophilia (> 15/hpf), and a PPI trial (persistent eosinophilia after 8 weeks of PPI). Mainstay of treatment at present is topical steroids and dietary therapy. Maintenance treatment should be considered to prevent long term complications.